SPRY1
Gene Ontology Biological Process
- bud elongation involved in lung branching [IGI]
- establishment of mitotic spindle orientation [IGI]
- metanephros development [IGI]
- negative regulation of ERK1 and ERK2 cascade [IDA, IGI]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- organ induction [IMP]
- ureteric bud development [IGI, IMP]
Gene Ontology Molecular Function
SPRY1
Gene Ontology Biological Process
- bud elongation involved in lung branching [IGI]
- establishment of mitotic spindle orientation [IGI]
- metanephros development [IGI]
- negative regulation of ERK1 and ERK2 cascade [IDA, IGI]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of Ras GTPase activity [IDA]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IDA]
- negative regulation of neurotrophin TRK receptor signaling pathway [IDA]
- organ induction [IMP]
- ureteric bud development [IGI, IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.
Strict regulation of the receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase (ERK) pathway is essential for maintaining balanced growth in multi-cellular organisms. Several negative regulators of the pathway have been identified which include Sprouty proteins. Mammalian cells express four Sprouty isoforms (Sprouty1-4) in an ERK-dependent manner. In this study, we have examined the molecular mechanisms by which Sprouty proteins elicit their ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID