GRIK3
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [ISO]
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [ISO]
- glutamate receptor signaling pathway [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- negative regulation of synaptic transmission, glutamatergic [ISO]
- regulation of membrane potential [ISO]
- signal transduction [ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIK2
Gene Ontology Biological Process
- behavioral fear response [IMP]
- cellular calcium ion homeostasis [IMP]
- intracellular protein transport [IDA]
- ion transmembrane transport [IGI]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of synaptic transmission, glutamatergic [IGI, ISO]
- neuron apoptotic process [ISO]
- neuronal action potential [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [ISO]
- regulation of JNK cascade [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of inhibitory postsynaptic membrane potential [IGI, IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IGI, IMP]
- regulation of short-term neuronal synaptic plasticity [IMP, ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [ISO]
- synaptic transmission [IGI, IMP, ISO]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IMP]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase binding [ISO]
- PDZ domain binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IMP]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IDA]
- ionotropic glutamate receptor complex [IC, ISO]
- kainate selective glutamate receptor complex [IPI]
- membrane [IDA]
- neuronal cell body [IDA]
- perikaryon [ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synapse [IDA, ISO, TAS]
- terminal bouton [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Differential trafficking of GluR7 kainate receptor subunit splice variants.
Kainate receptors (KARs) are heteromeric ionotropic glutamate receptors that play a variety of roles in the regulation of synaptic network activity. The function of glutamate receptors (GluRs) is highly dependent on their surface density in specific neuronal domains. Alternative splicing is known to regulate surface expression of GluR5 and GluR6 subunits. The KAR subunit GluR7 exists under different splice variant ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIK2 GRIK3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID