MAPK14
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- angiogenesis [IMP]
- cartilage condensation [IMP]
- cell morphogenesis [IGI]
- cellular response to DNA damage stimulus [IDA]
- cellular response to ionizing radiation [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- chondrocyte differentiation [IDA, IMP]
- fatty acid oxidation [IMP]
- glucose metabolic process [IMP]
- intracellular signal transduction [IDA, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- myoblast differentiation involved in skeletal muscle regeneration [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- osteoclast differentiation [IMP]
- p38MAPK cascade [IDA]
- peptidyl-serine phosphorylation [IDA]
- placenta development [IMP]
- positive regulation of brown fat cell differentiation [IMP]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of myoblast fusion [IMP]
- positive regulation of myotube differentiation [IMP]
- positive regulation of protein import into nucleus [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IMP]
- signal transduction in response to DNA damage [ISO]
- skeletal muscle tissue development [IMP]
- stress-activated MAPK cascade [ISO]
- stress-induced premature senescence [ISO]
- striated muscle cell differentiation [IGI]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHC1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [ISO]
- actin cytoskeleton reorganization [IMP]
- activation of MAPK activity [IMP, ISO]
- aging [ISO]
- angiogenesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA, IDA]
- heart development [IMP]
- insulin receptor signaling pathway [IBA, ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of vasoconstriction [ISO]
- regulation of cell proliferation [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.
The rac1 GTPase and the p66shc adaptor protein regulate intracellular levels of reactive oxygen species (ROS). We examined the relationship between rac1 and p66shc. Expression of constitutively active rac1 (rac1V12) increased phosphorylation, reduced ubiquitination, and increased stability of p66shc protein. Rac1V12-induced phosphorylation and up-regulation of p66shc was suppressed by inhibiting p38MAPK and was dependent on serine 54 and threonine 386 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID