CHRNA4
Gene Ontology Biological Process
- B cell activation [IMP]
- DNA repair [ISO]
- action potential [IMP]
- behavioral response to nicotine [IMP, ISO]
- calcium ion transport [IGI]
- cation transmembrane transport [IGI, ISO]
- cation transport [ISO]
- cognition [ISO]
- exploration behavior [IMP]
- ion transmembrane transport [IDA]
- locomotory behavior [IMP]
- membrane depolarization [IGI, IMP]
- neurological system process [IMP, ISO]
- positive regulation of dopamine secretion [ISO]
- protein heterooligomerization [ISO]
- regulation of dopamine secretion [IMP]
- regulation of inhibitory postsynaptic membrane potential [IMP]
- regulation of membrane potential [IGI]
- respiratory gaseous exchange [IMP]
- response to hypoxia [ISO]
- response to nicotine [IGI, IMP, ISO]
- response to oxidative stress [ISO]
- sensory perception of pain [IMP, TAS]
- signal transduction [ISO]
- synaptic transmission, cholinergic [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNA5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice.
The nicotinic receptor subtypes are important for several physiological functions in brain and may therefore play a critical role in brain development. The alpha7 nicotinic receptors which have high Ca2+ permeability are important for cognitive, neuroprotective and trophic functions. In this study, the brain development and the expression of alpha4, alpha3, alpha7, alpha5 and beta2 nicotinic receptors were investigated in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNA5 CHRNA4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID