RAF1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPKK activity [ISO]
- cell differentiation [IGI]
- death-inducing signaling complex assembly [IMP]
- intermediate filament cytoskeleton organization [IMP]
- intracellular signal transduction [TAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- negative regulation of protein complex assembly [ISO]
- neurotrophin TRK receptor signaling pathway [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [ISO, TAS]
- response to hypoxia [ISO]
- response to muscle stretch [IMP]
- somatic stem cell maintenance [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase kinase kinase activity [ISO]
- Ras GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [ISO]
- ATP binding [ISO]
- MAP kinase kinase kinase activity [ISO]
- Ras GTPase binding [IPI]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein kinase activity [TAS]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
KNDC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.
The regulation of cytoskeletal components in the dendritic shaft core is critical for dendrite elongation and branching. Here, we report that a brain-specific Ras guanine nucleotide exchange factor (RasGEF) carrying two kinase non-catalytic C-lobe domains (KINDs), very-KIND (v-KIND), regulates microtubule-associated protein 2 (MAP2). v-KIND is expressed in developing mouse brain, predominantly in the cerebellar granule cells. v-KIND not only activates ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID