BAIT
AIF1
AI607846, AIF-1, D17H6S50E, G1, Iba1
allograft inflammatory factor 1
GO Process (20)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- actin filament bundle assembly [IDA, ISO]
- actin filament polymerization [ISO]
- microglial cell activation [NAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of smooth muscle cell chemotaxis [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of T cell migration [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of monocyte chemotaxis [ISO]
- positive regulation of muscle hyperplasia [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of smooth muscle cell chemotaxis [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- ruffle assembly [IMP, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LCP1
CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, RP11-139H14.1
lymphocyte cytosolic protein 1 (L-plastin)
GO Process (6)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.
Ionized calcium binding adaptor molecule 1 (Iba1) is a microglia/macrophage-specific calcium-binding protein. Iba1 has the actin-bundling activity and participates in membrane ruffling and phagocytosis in activated microglia. In order to understand the Iba1-related intracellular signalling pathway in greater detail, we employed a yeast two-hybrid screen to isolate an Iba1-interacting molecule and identified another actin-bundling protein, L-fimbrin. In response to stimulation, ... [more]
J. Neurochem. Feb. 01, 2004; 88(4);844-56 [Pubmed: 14756805]
Throughput
- Low Throughput
Curated By
- BioGRID