BAIT

S100A8

60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8
S100 calcium binding protein A8
Autophagy Project
Homo sapiens
PREY

SEC27

L000001848, YGL137W
Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
GO Process (3)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Lethality

A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.

Publication

Aggregation of Human S100A8 and S100A9 Amyloidogenic Proteins Perturbs Proteostasis in a Yeast Model.

Eremenko E, Ben-Zvi A, Morozova-Roche LA, Raveh D

Amyloid aggregates of the calcium-binding EF-hand proteins, S100A8 and S100A9, have been found in the corpora amylacea of patients with prostate cancer and may play a role in carcinogenesis. Here we present a novel model system using the yeast Saccharomyces cerevisiae to study human S100A8 and S100A9 aggregation and toxicity. We found that S100A8, S100A9 and S100A8/9 cotransfomants form SDS-resistant ... [more]

PLoS ONE Mar. 14, 2013; 8(3);e58218 [Pubmed: 23483999]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: temperature sensitive growth (APO:0000092)

Additional Notes

  • expression of S100A8 or S100A9 in the srp1-31 or sec27-1 ts strains resulted in S100A8- and S100A9-dependent toxicity at 300C

Curated By

  • BioGRID