BAIT
BUR6
NCB1, L000003240, YER159C
Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p
GO Process (4)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
Gene Ontology Molecular Function- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
YRA1
SHE11, RNA-binding protein YRA1, L000002959, L000002873, YDR381W
Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member
GO Process (3)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.
The various steps of mRNP biogenesis (transcription, processing and export) are interconnected. It has been shown that the transcription machinery plays a pivotal role in mRNP assembly, since several mRNA export factors are recruited during transcription and physically interact with components of the transcription machinery. Although the shuttling DEAD-box protein Dbp5p is concentrated on the cytoplasmic fibrils of the NPC, ... [more]
BMC Genet. Sep. 12, 2012; 13(0);80 [Pubmed: 22963203]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- Synthetic lethality between bur6-ts and yra1-1 or sub2-85
Curated By
- BioGRID