BAIT

STIP1

HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
stress-induced phosphoprotein 1
GO Process (1)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

PWP2

UTP1, YCR055C, YCR058C, L000001540, YCR057C
Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model.

Footz T, Dubois S, Sarfarazi M, Raymond V, Walter MA

To investigate the role of multigenic variation in primary open-angle glaucoma (POAG) involving the rRNA processing gene WD repeat domain 36 (WDR36).We examined the heat shock protein 70/90 (HSP70/90)-organizing co-chaperone stress-induced-phosphoprotein 1 (STI1) as a potential co-modifying gene in glaucoma patients found to harbor WDR36 amino acid variation. The STI1 gene was sequenced and its POAG-associated amino acid variant K434R, ... [more]

Mol. Vis. Aug. 19, 2011; 17(0);1957-69 [Pubmed: 21850170]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Co-expression
  • D621G with hSTI1(P173T) caused
  • noticeably enhanced growth
  • of yeast UTP21 mutations L5P and

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
STIP1 PWP2
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
855125

Curated By

  • BioGRID