SLC8A1
Gene Ontology Biological Process
- calcium ion export [IDA, ISO]
- calcium ion homeostasis [ISO]
- calcium ion import [IDA, ISO]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [ISO, TAS]
- calcium ion transport into cytosol [IDA, ISO]
- cardiac muscle cell development [ISO]
- cardiac muscle contraction [ISO]
- cell communication by electrical coupling involved in cardiac conduction [IDA]
- cellular calcium ion homeostasis [IMP]
- cellular response to cAMP [IDA]
- cellular response to caffeine [ISO]
- cellular response to hypoxia [IEP]
- cellular response to reactive oxygen species [IDA, ISO]
- cellular sodium ion homeostasis [ISO]
- embryonic heart tube development [ISO]
- embryonic placenta development [ISO]
- heart morphogenesis [ISO]
- muscle fiber development [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast migration [IMP]
- positive regulation of the force of heart contraction [ISO]
- post-embryonic development [ISO]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IDA]
- regulation of heart rate [ISO]
- regulation of sodium ion transport [IMP]
- regulation of the force of heart contraction [ISO]
- relaxation of smooth muscle [ISO]
- response to ATP [IDA]
- response to drug [IEP]
- response to glucose [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IDA]
- response to immobilization stress [IEP]
- response to muscle stretch [ISO]
- response to nutrient [IEP]
- sodium ion export [IDA, ISO]
- sodium ion import [IDA, ISO]
- sodium ion transmembrane transport [ISO]
- sodium ion transport [IDA, ISO]
- telencephalon development [IEP]
- vascular smooth muscle contraction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA, ISO, TAS]
- Z disc [IDA]
- basolateral plasma membrane [ISO]
- cell [ISO]
- cell projection [IDA]
- cytosol [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- integral component of plasma membrane [ISO]
- intercalated disc [IDA]
- intracellular [ISO]
- membrane [ISO]
- microtubule [IDA]
- mitochondrion [IDA]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
ATP2A2
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- ER-nucleus signaling pathway [ISO]
- calcium ion import into sarcoplasmic reticulum [IDA]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [IDA]
- calcium ion transport from cytosol to endoplasmic reticulum [ISO]
- cellular calcium ion homeostasis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of heart contraction [ISO]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [ISO]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IDA]
- regulation of cardiac muscle cell membrane potential [IDA]
- regulation of cardiac muscle contraction by calcium ion signaling [IDA, ISO]
- regulation of muscle contraction [TAS]
- regulation of the force of heart contraction [ISO]
- relaxation of cardiac muscle [IDA, ISO]
- response to peptide hormone [IDA]
- sarcoplasmic reticulum calcium ion transport [IDA]
- transition between fast and slow fiber [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- S100 protein binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [IDA]
- enzyme binding [ISO]
- lutropin-choriogonadotropic hormone receptor binding [IPI]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- ATP binding [IDA]
- S100 protein binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [IDA]
- enzyme binding [ISO]
- lutropin-choriogonadotropic hormone receptor binding [IPI]
- protein C-terminus binding [ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [ISO]
- cell [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- intercalated disc [ISO]
- longitudinal sarcoplasmic reticulum [ISO]
- membrane [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
- sarcoplasmic reticulum [IDA, ISO, TAS]
- sarcoplasmic reticulum membrane [IC]
- vesicle membrane [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.
The possibility that certain integral plasma membrane (PM) proteins involved in Ca(2+) homeostasis form junctional units with adjacent endoplasmic reticulum (ER) in neurons and glia was explored using immunoprecipitation and immunocytochemistry. Rat brain membranes were solubilized with the mild, non-ionic detergent, IGEPAL CA-630. Na(+)/Ca(2+) exchanger type 1 (NCX1), a key PM Ca(2+) transporter, was immunoprecipitated from the detergent-soluble fraction. Several ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID