SLC8A1
Gene Ontology Biological Process
- calcium ion export [IDA, ISO]
- calcium ion homeostasis [ISO]
- calcium ion import [IDA, ISO]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [ISO, TAS]
- calcium ion transport into cytosol [IDA, ISO]
- cardiac muscle cell development [ISO]
- cardiac muscle contraction [ISO]
- cell communication by electrical coupling involved in cardiac conduction [IDA]
- cellular calcium ion homeostasis [IMP]
- cellular response to cAMP [IDA]
- cellular response to caffeine [ISO]
- cellular response to hypoxia [IEP]
- cellular response to reactive oxygen species [IDA, ISO]
- cellular sodium ion homeostasis [ISO]
- embryonic heart tube development [ISO]
- embryonic placenta development [ISO]
- heart morphogenesis [ISO]
- muscle fiber development [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast migration [IMP]
- positive regulation of the force of heart contraction [ISO]
- post-embryonic development [ISO]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IDA]
- regulation of heart rate [ISO]
- regulation of sodium ion transport [IMP]
- regulation of the force of heart contraction [ISO]
- relaxation of smooth muscle [ISO]
- response to ATP [IDA]
- response to drug [IEP]
- response to glucose [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IDA]
- response to immobilization stress [IEP]
- response to muscle stretch [ISO]
- response to nutrient [IEP]
- sodium ion export [IDA, ISO]
- sodium ion import [IDA, ISO]
- sodium ion transmembrane transport [ISO]
- sodium ion transport [IDA, ISO]
- telencephalon development [IEP]
- vascular smooth muscle contraction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA, ISO, TAS]
- Z disc [IDA]
- basolateral plasma membrane [ISO]
- cell [ISO]
- cell projection [IDA]
- cytosol [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- integral component of plasma membrane [ISO]
- intercalated disc [IDA]
- intracellular [ISO]
- membrane [ISO]
- microtubule [IDA]
- mitochondrion [IDA]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
ITPR1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cellular response to cAMP [IDA]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- inositol phosphate-mediated signaling [IDA, ISO, ISS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO, ISS]
- negative regulation of calcium-mediated signaling [ISO]
- negative regulation of neuron death [IMP]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- post-embryonic development [ISO]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- response to hypoxia [ISO]
- voluntary musculoskeletal movement [ISO]
Gene Ontology Molecular Function- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, ISS]
- intracellular ligand-gated calcium channel activity [ISO, ISS]
- phosphatidylinositol binding [ISO, ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein phosphatase binding [IDA]
- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, ISS]
- intracellular ligand-gated calcium channel activity [ISO, ISS]
- phosphatidylinositol binding [ISO, ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein phosphatase binding [IDA]
Gene Ontology Cellular Component
- calcineurin complex [ISO]
- cell [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [IDA, ISO, TAS]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- neuronal cell body [IDA]
- nuclear envelope [IDA, ISO]
- nuclear inner membrane [ISO]
- nucleolus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet dense granule membrane [ISO]
- platelet dense tubular network [ISO]
- postsynaptic density [IDA, ISO]
- protein complex [IDA, ISO]
- sarcoplasmic reticulum [IDA, ISO]
- secretory granule membrane [IDA]
- synaptic membrane [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.
The possibility that certain integral plasma membrane (PM) proteins involved in Ca(2+) homeostasis form junctional units with adjacent endoplasmic reticulum (ER) in neurons and glia was explored using immunoprecipitation and immunocytochemistry. Rat brain membranes were solubilized with the mild, non-ionic detergent, IGEPAL CA-630. Na(+)/Ca(2+) exchanger type 1 (NCX1), a key PM Ca(2+) transporter, was immunoprecipitated from the detergent-soluble fraction. Several ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ITPR1 SLC8A1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID