ATP1A2
Gene Ontology Biological Process
- ATP hydrolysis coupled proton transport [IMP]
- adult locomotory behavior [ISO]
- cardiac muscle contraction [IC]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [IDA, IEP]
- cellular response to steroid hormone stimulus [IMP, ISO]
- cellular sodium ion homeostasis [ISO]
- energy coupled proton transmembrane transport, against electrochemical gradient [TAS]
- locomotion [ISO]
- negative regulation of calcium ion transmembrane transport [IMP]
- negative regulation of calcium:sodium antiporter activity [IMP]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of striated muscle contraction [ISO]
- neurotransmitter uptake [ISO]
- potassium ion import [ISO]
- potassium ion transport [IDA]
- regulation of blood pressure [ISO]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IC]
- regulation of muscle contraction [ISO]
- regulation of respiratory gaseous exchange by neurological system process [ISO]
- regulation of smooth muscle contraction [ISO]
- regulation of striated muscle contraction [ISO]
- regulation of the force of heart contraction [ISO]
- regulation of vasoconstriction [ISO]
- relaxation of cardiac muscle [IC]
- response to glycoside [IMP, ISO]
- response to nicotine [IDA]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ITPR1
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cellular response to cAMP [IDA]
- cellular response to hypoxia [IEP]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- inositol phosphate-mediated signaling [IDA, ISO, ISS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO, ISS]
- negative regulation of calcium-mediated signaling [ISO]
- negative regulation of neuron death [IMP]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- post-embryonic development [ISO]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- response to hypoxia [ISO]
- voluntary musculoskeletal movement [ISO]
Gene Ontology Molecular Function- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, ISS]
- intracellular ligand-gated calcium channel activity [ISO, ISS]
- phosphatidylinositol binding [ISO, ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein phosphatase binding [IDA]
- calcium channel inhibitor activity [ISO]
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA, ISO, ISS]
- intracellular ligand-gated calcium channel activity [ISO, ISS]
- phosphatidylinositol binding [ISO, ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA]
- protein phosphatase binding [IDA]
Gene Ontology Cellular Component
- calcineurin complex [ISO]
- cell [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [IDA, ISO, TAS]
- intracellular [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- membrane raft [IDA]
- neuronal cell body [IDA]
- nuclear envelope [IDA, ISO]
- nuclear inner membrane [ISO]
- nucleolus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet dense granule membrane [ISO]
- platelet dense tubular network [ISO]
- postsynaptic density [IDA, ISO]
- protein complex [IDA, ISO]
- sarcoplasmic reticulum [IDA, ISO]
- secretory granule membrane [IDA]
- synaptic membrane [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.
The possibility that certain integral plasma membrane (PM) proteins involved in Ca(2+) homeostasis form junctional units with adjacent endoplasmic reticulum (ER) in neurons and glia was explored using immunoprecipitation and immunocytochemistry. Rat brain membranes were solubilized with the mild, non-ionic detergent, IGEPAL CA-630. Na(+)/Ca(2+) exchanger type 1 (NCX1), a key PM Ca(2+) transporter, was immunoprecipitated from the detergent-soluble fraction. Several ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID