BAIT
MMS19
MET18, MMS19L, hMMS19, RP11-452K12.5
MMS19 nucleotide excision repair homolog (S. cerevisiae)
GO Process (11)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA metabolic process [IMP]
- DNA repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome segregation [IMP]
- iron-sulfur cluster assembly [IMP]
- nucleotide-excision repair [NAS, TAS]
- phosphorelay signal transduction system [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- response to hormone [NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSE1L
CAS, CSE1, XPO2
CSE1 chromosome segregation 1-like (yeast)
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity, but the molecular basis of this connection is unknown. Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery. MMS19 functions as part of the CIA targeting complex that specifically interacts with and ... [more]
Science Jul. 13, 2012; 337(6091);195-9 [Pubmed: 22678362]
Throughput
- High Throughput
Curated By
- BioGRID