BAIT
MMS19
MET18, MMS19L, hMMS19, RP11-452K12.5
MMS19 nucleotide excision repair homolog (S. cerevisiae)
GO Process (11)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA metabolic process [IMP]
- DNA repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome segregation [IMP]
- iron-sulfur cluster assembly [IMP]
- nucleotide-excision repair [NAS, TAS]
- phosphorelay signal transduction system [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- response to hormone [NAS]
- small molecule metabolic process [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DICER1
DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
dicer 1, ribonuclease type III
GO Process (15)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, IMP]
- conversion of ds siRNA to ss siRNA [IMP]
- gene expression [TAS]
- negative regulation of Schwann cell proliferation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nerve development [ISS]
- neuron projection morphogenesis [ISS]
- peripheral nervous system myelin formation [ISS]
- positive regulation of Schwann cell differentiation [ISS]
- positive regulation of myelination [ISS]
- pre-miRNA processing [IDA]
- production of miRNAs involved in gene silencing by miRNA [ISS]
- production of siRNA involved in RNA interference [IDA]
- targeting of mRNA for destruction involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity, but the molecular basis of this connection is unknown. Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery. MMS19 functions as part of the CIA targeting complex that specifically interacts with and ... [more]
Science Jul. 13, 2012; 337(6091);195-9 [Pubmed: 22678362]
Throughput
- High Throughput
Curated By
- BioGRID