BAIT
HES1
HES-1, HHL, HRY, bHLHb39
hes family bHLH transcription factor 1
GO Process (32)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
- Notch signaling pathway [IDA, IMP, TAS]
- STAT protein import into nucleus [ISS]
- artery morphogenesis [ISS]
- ascending aorta morphogenesis [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- embryonic heart tube morphogenesis [ISS]
- endocrine pancreas development [TAS]
- forebrain radial glial cell differentiation [ISS]
- negative regulation of forebrain neuron differentiation [ISS]
- negative regulation of glial cell proliferation [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of pro-B cell differentiation [IMP]
- negative regulation of stem cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neuronal stem cell maintenance [IEP]
- outflow tract morphogenesis [ISS]
- pharyngeal arch artery morphogenesis [ISS]
- positive regulation of DNA binding [ISS]
- positive regulation of JAK-STAT cascade [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of mitotic cell cycle, embryonic [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein complex assembly [ISS]
- regulation of secondary heart field cardioblast proliferation [ISS]
- thymus development [ISS]
- vascular smooth muscle cell development [ISS]
- ventricular septum development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- DNA binding [TAS]
- N-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
- nucleus [ISS]
Homo sapiens
PREY
JAK2
JTK10, THCYT3
Janus kinase 2
GO Process (49)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISS, TAS]
- STAT protein import into nucleus [ISS]
- actin filament polymerization [NAS]
- activation of JAK2 kinase activity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISS]
- apoptotic process [ISS]
- blood coagulation [TAS]
- cell differentiation [ISS]
- cell migration [IBA]
- cellular component movement [TAS]
- cytokine-mediated signaling pathway [IDA, ISS, TAS]
- enzyme linked receptor protein signaling pathway [ISS]
- erythrocyte differentiation [IBA, ISS]
- extrinsic apoptotic signaling pathway [ISS]
- growth hormone receptor signaling pathway [IDA]
- histone H3-Y41 phosphorylation [IDA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- interleukin-12-mediated signaling pathway [IDA]
- intracellular signal transduction [ISS]
- mammary gland epithelium development [ISS]
- mesoderm development [TAS]
- negative regulation of DNA binding [ISS]
- negative regulation of cell proliferation [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- positive regulation of growth hormone receptor signaling pathway [ISS]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [TAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of inflammatory response [IDA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- response to antibiotic [IDA]
- response to interleukin-12 [IDA]
- response to lipopolysaccharide [ISS]
- response to tumor necrosis factor [IDA]
- signal transduction [ISS]
- tumor necrosis factor-mediated signaling pathway [IDA]
- tyrosine phosphorylation of STAT protein [IBA, ISS]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.
Although the Notch and JAK-STAT signalling pathways fulfill overlapping roles in growth and differentiation regulation, no coordination mechanism has been proposed to explain their relationship. Here we show that STAT3 is activated in the presence of active Notch, as well as the Notch effectors Hes1 and Hes5. Hes proteins associate with JAK2 and STAT3, and facilitate complex formation between JAK2 ... [more]
Nat. Cell Biol. Jun. 01, 2004; 6(6);547-54 [Pubmed: 15156153]
Throughput
- Low Throughput
Curated By
- BioGRID