CALM1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- activation of adenylate cyclase activity [IDA]
- calcium-mediated signaling [IMP]
- detection of calcium ion [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of cyclic nucleotide metabolic process [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cytokinesis [ISO]
- regulation of heart rate [ISO]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of store-operated calcium channel activity [IC]
- response to amphetamine [IEP]
- response to calcium ion [ISO]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
TSC1
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [ISO]
- cell projection organization [ISO]
- cell-matrix adhesion [ISO]
- cerebral cortex development [ISO]
- glucose import [ISO]
- hippocampus development [ISO]
- kidney development [ISO]
- myelination [ISO]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell size [ISO]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [ISO]
- neural tube closure [ISO]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [ISO]
- protein heterooligomerization [IDA]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [IMP]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [ISO]
- regulation of stress fiber assembly [IMP, ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cross-talk between tuberin, calmodulin, and estrogen signaling pathways.
Lymphangioleiomyomatosis (LAM) is a rare disease that occurs primarily in women and has been linked to both estrogen-mediated signaling events and mutations associated with the tuberous sclerosis complex 2 gene product tuberin. These two observations fostered the hypothesis that tuberin's impact on estrogen-mediated signaling might be through a direct interaction with the intracellular receptor for estrogen, estrogen receptor alpha (ERalpha). ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID