Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Novel interaction partners of Bardet-Biedl syndrome proteins.

Oeffner F, Moch C, Neundorf A, Hofmann J, Koch M, Grzeschik KH

Bardet-Biedl syndrome (BBS) is a rare, developmental disorder characterized by six major symptoms: rod-cone dystrophy, obesity, polydactyly, renal abnormalities, learning difficulties, and hypogonadism. Secondary features include cardiac and hepatic anomalies, metabolic disturbancies, and hearing loss. BBS is genetically heterogeneous with 12 disease genes (BBS1-BBS12) described thus far. Current data suggest a functional disturbance in ciliary function and intraflagellar transport being ... [more]

Cell Motil. Cytoskeleton Feb. 01, 2008; 65(2);143-55 [Pubmed: 18000879]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

BBS1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II repressing transcription factor binding [IPI]patched binding [IPI]protein binding [IPI]smoothened binding [IPI]

Gene Ontology Cellular Component

EEF1A1

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTP binding [TAS]poly(A) RNA binding [IDA]protein binding [IPI]protein kinase binding [IPI]translation elongation factor activity [TAS]

Gene Ontology Cellular Component

Two-hybrid

Publication

Novel interaction partners of Bardet-Biedl syndrome proteins.

Throughput

Curated By

RNA polymerase II repressing transcription factor binding [IPI]
patched binding [IPI]
protein binding [IPI]
smoothened binding [IPI]

GTP binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation elongation factor activity [TAS]