NFKB1
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IBA]
- NIK/NF-kappaB signaling [IBA]
- cellular response to interleukin-6 [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to nicotine [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to stress [IBA]
- innate immune response [IBA]
- lymph node development [TAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of calcidiol 1-monooxygenase activity [ISO]
- negative regulation of cytokine production [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-12 biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of hyaluronan biosynthetic process [ISO]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- response to cytokine [IBA]
- response to muscle stretch [IDA]
- response to oxidative stress [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- heat shock protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- regulatory region DNA binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- heat shock protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- regulatory region DNA binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
MAP3K8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The tyrosine kinase Syk regulates TPL2 activation signals.
Tpl2/Cot is a serine/threonine kinase that plays a key physiological role in the regulation of immune responses to pro-inflammatory stimuli, including tumor necrosis factor-alpha (TNF-alpha). TNF-alpha stimulates the JNK, ERK, and p38 mitogen-activated protein kinases and the NF-kappaB pathway by recruiting RIP1 and TRAF2 to the TNF receptor 1. Here we showed that Tpl2 activation by TNF-alpha signals depends on ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NFKB1 MAP3K8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID