BAIT
XPO1
CRM1, emb, exp1
exportin 1
GO Process (12)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STAT1
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
signal transducer and activator of transcription 1, 91kDa
GO Process (32)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- apoptotic process [ISS]
- blood circulation [ISS]
- cellular response to interferon-beta [IMP]
- cytokine-mediated signaling pathway [TAS]
- endothelial cell migration [IMP]
- interferon-gamma-mediated signaling pathway [IDA, ISS, TAS]
- metanephric mesenchymal cell differentiation [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- negative regulation by virus of viral protein levels in host cell [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- negative regulation of metanephric nephron tubule epithelial cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of apoptotic process [TAS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- renal tubule development [IMP]
- response to cAMP [ISS]
- response to cytokine [ISS]
- response to peptide hormone [ISS]
- transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [IDA]
- type I interferon signaling pathway [ISS, TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- tumor necrosis factor receptor binding [IPI]
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Sequence and structural analyses of nuclear export signals in the NESdb database.
We compiled >200 nuclear export signal (NES)-containing CRM1 cargoes in a database named NESdb. We analyzed the sequences and three-dimensional structures of natural, experimentally identified NESs and of false-positive NESs that were generated from the database in order to identify properties that might distinguish the two groups of sequences. Analyses of amino acid frequencies, sequence logos, and agreement with existing ... [more]
Mol. Biol. Cell Sep. 01, 2012; 23(18);3677-93 [Pubmed: 22833565]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| XPO1 STAT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1439813 |
Curated By
- BioGRID