BAIT
CAPN1
CANP, CANP1, CANPL1, muCANP, muCL, PIG30
calpain 1, (mu/I) large subunit
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLIT3
MEGF5, SLIL2, SLIT1, Slit-3, slit2, UNQ691/PRO1336
slit homolog 3 (Drosophila)
GO Process (10)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- Roundabout signaling pathway [IMP]
- apoptotic process involved in luteolysis [IEP]
- axon extension involved in axon guidance [IDA]
- axon guidance [IDA, TAS]
- cellular response to hormone stimulus [IEP]
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration [IDA]
- negative chemotaxis [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of chemokine-mediated signaling pathway [IMP]
- response to cortisol [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.
Calpain, a cytosolic cysteine protease, requires calcium ions for activity. It has been reported that calpain is involved in the degradation of myofibrillar and neurofilament proteins, and the activation of phosphorylase b kinase and protein kinase C. More recently, calpain was shown to participate in apoptosis. In order to understand the calpain-related signal transduction pathway and its changes during hypertrophy, ... [more]
Hypertens. Res. Jul. 01, 2002; 25(4);647-52 [Pubmed: 12358155]
Throughput
- Low Throughput
Curated By
- BioGRID