BAIT
CAPN1
CANP, CANP1, CANPL1, muCANP, muCL, PIG30
calpain 1, (mu/I) large subunit
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
COL1A1
OI4
collagen, type I, alpha 1
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood vessel development [IMP]
- collagen biosynthetic process [IMP]
- collagen catabolic process [TAS]
- collagen fibril organization [IMP]
- embryonic skeletal system development [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- platelet activation [TAS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IDA]
- sensory perception of sound [IMP]
- skeletal system development [IMP]
- skin morphogenesis [IMP]
- tooth mineralization [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.
Calpain, a cytosolic cysteine protease, requires calcium ions for activity. It has been reported that calpain is involved in the degradation of myofibrillar and neurofilament proteins, and the activation of phosphorylase b kinase and protein kinase C. More recently, calpain was shown to participate in apoptosis. In order to understand the calpain-related signal transduction pathway and its changes during hypertrophy, ... [more]
Hypertens. Res. Jul. 01, 2002; 25(4);647-52 [Pubmed: 12358155]
Throughput
- Low Throughput
Curated By
- BioGRID