An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.

Bharucha DC, Zhou M, Nekhai S, Brady JN, Shukla RR, Kumar A

HIV-1 Tat protein regulates viral gene expression by modulating the activity and association of cellular transcription factors with RNA polymerase II (RNAPII). Possible mechanisms include Tat-associated protein kinase(s) and phosphatase(s) that regulate phosphorylation of the C-terminal domain (CTD) of the large subunit of RNAPII. Hypophosphorylated RNAPII (RNAPIIa) is recruited to promoters during formation of a preinitiation complex, whereas hyperphosphorylated RNAPII ... [more]

Virology Apr. 25, 2002; 296(1);6-16 [Pubmed: 12036313]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

CTDP1

Gene Ontology Biological Process

Gene Ontology Molecular Function

CTD phosphatase activity [IDA]DNA-directed RNA polymerase activity [TAS]

Gene Ontology Cellular Component

UPP1