BAIT
RGS12
regulator of G-protein signaling 12
GO Process (4)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAP2K2
AA589381, MEK2, MK2, Prkmk2
mitogen-activated protein kinase kinase 2
GO Process (9)
GO Function (8)
GO Component (15)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPK activity [ISO, TAS]
- peptidyl-serine autophosphorylation [ISO]
- positive regulation of cell motility [IDA]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein phosphorylation [ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO, TAS]
- cell cortex [ISO]
- cell-cell junction [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- cytosol [ISO, TAS]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [ISO]
- mitochondrion [TAS]
- nucleus [TAS]
- perinuclear region of cytoplasm [ISO]
- peroxisomal membrane [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
Regulator of G-protein signaling (RGS) proteins accelerate GTP hydrolysis by heterotrimeric G-protein alpha subunits and thus inhibit signaling by many G protein-coupled receptors. Several RGS proteins have a multidomain architecture that adds further complexity to their roles in cell signaling in addition to their GTPase-accelerating activity. RGS12 contains a tandem repeat of Ras-binding domains but, to date, the role of ... [more]
EMBO J. Apr. 18, 2007; 26(8);2029-40 [Pubmed: 17380122]
Throughput
- Low Throughput
Curated By
- BioGRID