TTR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MT3
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- activation of protein kinase B activity [IDA]
- astrocyte development [ISS]
- cadmium ion homeostasis [IDA]
- cell proliferation [TAS]
- cellular lipid catabolic process [ISS]
- cellular metal ion homeostasis [NAS, TAS]
- cellular response to cadmium ion [IDA]
- cellular response to drug [IDA]
- cellular response to hypoxia [IEP]
- cellular response to nitric oxide [IDA]
- cellular response to oxidative stress [IEP]
- cellular zinc ion homeostasis [ISS]
- cholesterol catabolic process [ISS]
- energy reserve metabolic process [ISS]
- histone modification [IMP]
- leptin-mediated signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of autophagy [ISS]
- negative regulation of axon extension [IDA]
- negative regulation of cell growth [IDA, IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of necrotic cell death [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of oxidoreductase activity [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of catalytic activity [ISS]
- positive regulation of cell death [IDA, ISS]
- positive regulation of gene expression [IDA, ISS]
- positive regulation of lysosomal membrane permeability [ISS]
- positive regulation of necrotic cell death [IDA]
- positive regulation of oxygen metabolic process [ISS]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IDA]
- protein stabilization [IDA]
- regulation of protein glycosylation [ISS]
- regulation of response to food [ISS]
- removal of superoxide radicals [IDA]
- response to hypoxia [IDA]
- zinc ion homeostasis [IDA]
- zinc ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin.
Transthyretin (TTR), an amyloid-beta (Abeta) scavenger protein, and metallothioneins 2 and 3 (MT2 and MT3), low molecular weight metal-binding proteins, have recognized impacts in Abeta metabolism. Because TTR binds MT2, an ubiquitous isoform of the MTs, we investigated whether it also interacts with MT3, an isoform of the MTs predominantly expressed in the brain, and studied the role of MT2 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TTR MT3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TTR MT3 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - | |
| TTR MT3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID