BAIT

KARS

CMTRIB, DFNB89, KARS1, KARS2, KRS
lysyl-tRNA synthetase
GO Process (4)
GO Function (3)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

MSK1

lysine--tRNA ligase MSK1, L000001195, YNL073W
Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
GO Process (4)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria.

Sepuri NB, Gorla M, King MP

Aminoacyl tRNA synthetases play a central role in protein synthesis by charging tRNAs with amino acids. Yeast mitochondrial lysyl tRNA synthetase (Msk1), in addition to the aminoacylation of mitochondrial tRNA, also functions as a chaperone to facilitate the import of cytosolic lysyl tRNA. In this report, we show that human mitochondrial Kars (lysyl tRNA synthetase) can complement the growth defect ... [more]

PLoS ONE Apr. 28, 2012; 7(4);e35321 [Pubmed: 22539966]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: fermentative metabolism (APO:0000101)
  • phenotype: respiratory metabolism (APO:0000102)

Additional Notes

  • Cells expressing high levels of human KARS partially suppressed the growth defect of msk1D cells on both fermentable and on non-fermentable carbon sources

Curated By

  • BioGRID