CHL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
POL30
Gene Ontology Biological Process
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- error-free translesion synthesis [IGI]
- establishment of mitotic sister chromatid cohesion [IGI]
- lagging strand elongation [IDA, IPI]
- leading strand elongation [IDA]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- meiotic mismatch repair [IGI, IMP]
- mismatch repair [IGI, IMP, IPI]
- mitotic cell cycle [IGI]
- mitotic sister chromatid cohesion [IGI, IPI]
- nucleotide-excision repair [IMP]
- positive regulation of exodeoxyribonuclease activity [IDA]
- positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [IDA]
- postreplication repair [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway.
Fanconi anemia (FA) is a human syndrome characterized by genomic instability and increased incidence of cancer. FA is a genetically heterogeneous disease caused by mutations in at least 15 different genes; several of these genes are conserved in the yeast Saccharomyces cerevisiae. Elg1 is also a conserved protein that forms an RFC-like complex, which interacts with SUMOylated PCNA. The mammalian ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- In contrast to these results, pol30-RR exhibited increased sensitivity to MMS when combined with elg1D or chl1D, and evenmore sensitivity when the three mutants were combined
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHL1 POL30 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -15.2403 | BioGRID | 213432 | |
| POL30 CHL1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2124 | BioGRID | 1960764 | |
| CHL1 POL30 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 3492424 | |
| CHL1 POL30 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low/High | 0.0013 | BioGRID | 818571 |
Curated By
- BioGRID