PRKCB
Gene Ontology Biological Process
- B cell activation [IMP]
- B cell receptor signaling pathway [IMP]
- calcium ion transport [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to carbohydrate stimulus [IDA]
- histone H3-T6 phosphorylation [ISO]
- negative regulation of glucose transport [IMP]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of B cell receptor signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- protein phosphorylation [IDA]
- regulation of dopamine secretion [ISO]
- regulation of growth [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to drug [ISO]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium channel regulator activity [IDA]
- chromatin binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-T6 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [IDA]
- androgen receptor binding [ISO]
- calcium channel regulator activity [IDA]
- chromatin binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-T6 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [IDA]
Gene Ontology Cellular Component
RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cell division [IMP]
- cell morphogenesis involved in neuron differentiation [IMP]
- digestive tract development [IMP]
- enucleate erythrocyte differentiation [IGI]
- glial cell apoptotic process [IMP]
- hepatocyte apoptotic process [IMP, ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- myoblast differentiation [ISO]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron apoptotic process [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein localization to chromosome, centromeric region [ISO]
- regulation of cell cycle [IMP]
- regulation of cohesin localization to chromatin [ISO]
- regulation of lipid kinase activity [ISO]
- regulation of mitotic cell cycle [ISO]
- sister chromatid biorientation [ISO]
- skeletal muscle cell differentiation [IMP]
- striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization.
Retinal neovascularization is a major cause of blindness and requires the activities of several signaling pathways and multiple cytokines. Activation of protein kinase C (PKC) enhances the angiogenic process and is involved in the signaling of vascular endothelial growth factor (VEGF). We have demonstrated a dramatic increase in the angiogenic response to oxygen-induced retinal ischemia in transgenic mice overexpressing PKC ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RB1 PRKCB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID