BAIT
MYCBP2
PAM, AC001226.5
MYC binding protein 2, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Homo sapiens
PREY
ROBO2
SAX3
roundabout, axon guidance receptor, homolog 2 (Drosophila)
GO Process (14)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process involved in luteolysis [IEP]
- axon guidance [ISS, TAS]
- axon midline choice point recognition [ISS]
- brain development [IEP]
- cellular response to hormone stimulus [IEP]
- central nervous system development [NAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- metanephros development [ISS]
- negative regulation of negative chemotaxis [IDA]
- negative regulation of synapse assembly [ISS]
- olfactory bulb interneuron development [ISS]
- positive regulation of axonogenesis [IDA]
- retinal ganglion cell axon guidance [ISS]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system.
The E3 ubiquitin ligase Mycbp2 and it homologues play an important role in axon guidance and synaptogenesis in Drosophila, Caenorhabditis elegans, zebrafish and mouse. Despite this conserved function, the molecular and cellular basis of Mycbp2-dependent axon guidance remains largely unclear. We have examined here the effect of the loss-of-MYCBP2 function on the topography of the olfactory sensory neuron projection from ... [more]
Brain Struct Funct Mar. 24, 2013; 0(0); [Pubmed: 23525682]
Throughput
- Low Throughput
Additional Notes
- absence of the hippocampal commissure
- of the second Mycbp2 allele resulted in the complete
- on hippocampal commissural formation, the additional loss
- simultaneous loss of one allele of both genes had no effect
- strong genetic interactions between Mycbp2 and Robo2 in
- the formation of the hippocampal commissure. While the
- there were
Curated By
- BioGRID