MIB1
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- blood vessel development [IMP]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- negative regulation of neuron differentiation [IMP]
- neural tube formation [IMP]
- positive regulation of endocytosis [IDA]
- protein ubiquitination [IBA]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DAPK1
Gene Ontology Biological Process
- apoptotic process [ISO]
- apoptotic signaling pathway [ISO, TAS]
- cellular response to interferon-gamma [IMP, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- intracellular signal transduction [IDA, ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of translation [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, IDA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation.
After cell fate specification, differentiating cells must amplify the specific subcellular features required for their specialized function. How cells regulate such subcellular scaling is a fundamental unanswered question. Here, we show that the E3 ubiquitin ligase Mindbomb 1 (MIB1) is required for the apical secretory apparatus established by gastric zymogenic cells as they differentiate from their progenitors. When Mib1 was ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MIB1 DAPK1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.807 | BioGRID | 2679446 |
Curated By
- BioGRID