BAIT
AR
AW320017, Tfm, RP23-405B8.1
androgen receptor
GO Process (51)
GO Function (18)
GO Component (7)
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- activation of prostate induction by androgen receptor signaling pathway [IMP]
- androgen receptor signaling pathway [IDA, ISO]
- cellular process [IDA]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial cell morphogenesis [IGI]
- fertilization [IMP]
- in utero embryonic development [IMP]
- intracellular receptor signaling pathway [ISO]
- lateral sprouting involved in mammary gland duct morphogenesis [IMP]
- male genitalia morphogenesis [IMP]
- male gonad development [IGI, IMP]
- male sex differentiation [ISO]
- male somatic sex determination [IMP]
- mammary gland alveolus development [IMP]
- morphogenesis of an epithelial fold [IMP]
- multicellular organism growth [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of integrin biosynthetic process [ISO]
- organ formation [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [IMP]
- positive regulation of integrin biosynthetic process [ISO]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate gland epithelium morphogenesis [IMP]
- prostate gland growth [IMP]
- protein oligomerization [ISO]
- regulation of catalytic activity [IMP]
- regulation of developmental growth [IMP]
- regulation of establishment of protein localization to plasma membrane [ISO]
- regulation of gene expression [IMP]
- regulation of prostatic bud formation [IGI]
- regulation of systemic arterial blood pressure [IGI]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- reproductive structure development [IMP]
- reproductive system development [IGI]
- seminiferous tubule development [IGI, IMP]
- single fertilization [IGI]
- spermatogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tertiary branching involved in mammary gland duct morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- POU domain binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II transcription factor binding [ISO]
- androgen binding [ISO]
- androgen receptor activity [IDA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [ISO]
- enzyme binding [IPI, ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- receptor binding [ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Mus musculus
PREY
HSPA5
AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP, RP23-446N16.1
heat shock protein 5
GO Process (15)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of signaling protein activity involved in unfolded protein response [IMP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [IDA]
- cerebellar Purkinje cell layer development [IMP]
- cerebellum structural organization [IMP]
- maintenance of protein localization in endoplasmic reticulum [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of embryonic development [TAS]
- positive regulation of protein ubiquitination [IMP]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to endoplasmic reticulum stress [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [IDA]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [IDA]
- endoplasmic reticulum membrane [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [ISO]
- midbody [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells.
Commitment of differentiating embryonic stem cells (ESCs) toward the various lineages is influenced by many factors, including androgens. However, the mechanisms underlying proteotoxic stress conferred by androgen receptor (AR) actions on embryonic cell fate remains unclear. Here we show that mouse ESCs display stress-related cellular phenotypes in response to androgens during early phase of differentiation. Androgen induced a significant increase ... [more]
Cell Death Dis Apr. 27, 2013; 4(0);e607 [Pubmed: 23618905]
Throughput
- Low Throughput
Curated By
- BioGRID