TIMP3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AGTR2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IC]
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [ISS]
- angiotensin-activated signaling pathway [IPI, TAS]
- blood vessel remodeling [TAS]
- brain development [NAS]
- cell surface receptor signaling pathway [IDA]
- extracellular negative regulation of signal transduction [TAS]
- intracellular signal transduction [ISS]
- negative regulation of blood vessel endothelial cell migration [NAS]
- negative regulation of cell growth [TAS]
- negative regulation of heart rate [ISS]
- negative regulation of neurotrophin TRK receptor signaling pathway [IMP]
- nitric oxide mediated signal transduction [IC, TAS]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of nitric oxide biosynthetic process [IC]
- positive regulation of nitric-oxide synthase activity [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of vasodilation [IDA]
- regulation of blood pressure [TAS]
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Lethality
A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
Publication
Tissue inhibitor of metalloproteinases-3 interacts with angiotensin II type 2 receptor and additively inhibits angiogenesis.
The tissue inhibitors of metalloproteinases (TIMPs) are complex molecules with both pro- and anti-tumour effects. Thus, their diverse expression could be because of their multifunctional properties with respect to tumour growth, angiogenesis, apoptosis, and other biological functions. Previous data have shown that TIMPs bind tightly to most matrix metalloproteinases, although the pathway that mediates angiostatic activity has not been fully ... [more]
Throughput
- Low Throughput
Additional Notes
- accelerated apoptotic death due to increased caspase-3 activity
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TIMP3 AGTR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AGTR2 TIMP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 859773 | |
| TIMP3 AGTR2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 859775 | |
| TIMP3 AGTR2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 858692 |
Curated By
- BioGRID