BAIT
JAK2
Janus kinase 2
GO Process (75)
GO Function (17)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- JAK-STAT cascade [IDA, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO, ISS]
- STAT protein import into nucleus [ISO]
- activation of JAK2 kinase activity [ISO, ISS]
- activation of MAPKK activity [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- axon regeneration [IMP]
- cell differentiation [ISO]
- cellular response to dexamethasone stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [ISO, ISS]
- enzyme linked receptor protein signaling pathway [ISO]
- erythrocyte differentiation [IBA, ISO, ISS]
- extrinsic apoptotic signaling pathway [ISO]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO, ISS]
- hormone-mediated signaling pathway [IDA]
- host programmed cell death induced by symbiont [ISO]
- interferon-gamma-mediated signaling pathway [IDA]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- mammary gland epithelium development [ISO]
- mineralocorticoid receptor signaling pathway [IMP]
- myeloid cell differentiation [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-cell adhesion [IMP]
- negative regulation of heart contraction [IMP]
- negative regulation of neuron apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive regulation of DNA binding [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell activation [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of growth hormone receptor signaling pathway [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of phosphoprotein phosphatase activity [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO, ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- protein autophosphorylation [IMP, ISO, ISS]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to hydroperoxide [IMP]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [ISO]
- response to oxidative stress [IMP]
- response to tumor necrosis factor [ISO]
- signal transduction [ISO, ISS]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [ISO]
- tyrosine phosphorylation of Stat1 protein [IMP]
- tyrosine phosphorylation of Stat3 protein [IMP]
- tyrosine phosphorylation of Stat5 protein [IMP]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [IPI]
- growth hormone receptor binding [IPI]
- heme binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-Y41 specific) [IBA, ISO, ISS]
- insulin receptor substrate binding [IPI]
- interleukin-12 receptor binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IMP, ISO, ISS]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [IPI]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [IPI]
- growth hormone receptor binding [IPI]
- heme binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-Y41 specific) [IBA, ISO, ISS]
- insulin receptor substrate binding [IPI]
- interleukin-12 receptor binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IMP, ISO, ISS]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
NFKBIA
RL/IF-1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
GO Process (22)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [IMP, ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Notch signaling pathway [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of myeloid cell differentiation [ISO]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein import into nucleus, translocation [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to muramyl dipeptide [ISO]
- response to muscle stretch [ISO]
- toll-like receptor 4 signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades.
Erythropoietin, a kidney cytokine regulating haematopoiesis (the production of blood cells), is also produced in the brain after oxidative or nitrosative stress. The transcription factor hypoxia-inducible factor-1 (HIF-1) upregulates EPO following hypoxic stimuli. Here we show that preconditioning with EPO protects neurons in models of ischaemic and degenerative damage due to excitotoxins and consequent generation of free radicals, including nitric ... [more]
Nature Aug. 09, 2001; 412(6847);641-7 [Pubmed: 11493922]
Throughput
- Low Throughput
Curated By
- BioGRID