GRIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ALS2
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- axonogenesis [ISO]
- behavioral fear response [IMP]
- cell death [ISO]
- endosomal transport [IMP]
- endosome organization [ISO]
- locomotory behavior [IMP]
- lysosomal transport [ISO]
- neuromuscular junction development [IMP]
- neuron projection morphogenesis [ISO]
- positive regulation of Rab GTPase activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein homooligomerization [ISO]
- protein localization [IMP]
- receptor recycling [IMP]
- regulation of Rab GTPase activity [IDA]
- response to oxidative stress [IMP]
- synaptic transmission, glutamatergic [IMP]
- vesicle organization [IDA]
Gene Ontology Molecular Function- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
- Rab GTPase activator activity [ISO]
- Rab GTPase binding [ISO]
- Rab guanyl-nucleotide exchange factor activity [ISO]
- Rac GTPase activator activity [ISO]
- Rac GTPase binding [ISO]
- Rac guanyl-nucleotide exchange factor activity [ISO]
- guanyl-nucleotide exchange factor activity [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic spine [IDA]
- early endosome [ISO]
- growth cone [ISO]
- intracellular [IMP]
- intracellular membrane-bounded organelle [ISO]
- lamellipodium [IDA]
- membrane [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
- ruffle [IDA]
- vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease is caused by a selective loss of motor neurons. One form of juvenile onset autosomal recessive ALS (ALS2) has been linked to the loss of function of the ALS2 gene. The pathogenic mechanism of ALS2-deficiency, however, remains unclear. To further understand the function of alsin that is encoded by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ALS2 GRIP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ALS2 GRIP1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID