BAIT
GPC3
OCI-5
glypican 3
GO Process (26)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- anterior/posterior axis specification [ISO]
- body morphogenesis [ISO]
- bone mineralization [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cell proliferation involved in kidney development [ISO]
- cell proliferation involved in metanephros development [ISO]
- coronary vasculature development [ISO]
- embryonic hindlimb morphogenesis [ISO]
- kidney development [ISO]
- lung development [ISO]
- mesenchymal cell proliferation involved in ureteric bud development [ISO]
- mesonephric duct morphogenesis [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of growth [ISO]
- negative regulation of smoothened signaling pathway [ISO]
- organ morphogenesis [ISO]
- osteoclast differentiation [ISO]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- regulation of growth [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SHH
9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081
sonic hedgehog
GO Process (189)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IDA]
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [IMP, ISO]
- T cell differentiation in thymus [IMP]
- anatomical structure development [IMP]
- anatomical structure formation involved in morphogenesis [IMP]
- androgen metabolic process [IMP]
- angiogenesis [IDA, IGI, IMP]
- anterior/posterior pattern specification [IMP]
- apoptotic process [IGI]
- apoptotic signaling pathway [IDA]
- artery development [IGI, IMP]
- axon guidance [IDA, IMP]
- blood coagulation [IMP]
- branching involved in prostate gland morphogenesis [IDA]
- branching involved in salivary gland morphogenesis [IGI, IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- branching morphogenesis of an epithelial tube [IMP]
- bud outgrowth involved in lung branching [IMP]
- camera-type eye development [IDA, IGI, IMP]
- canonical Wnt signaling pathway [IDA]
- cell development [IMP]
- cell fate commitment [IGI]
- cell fate specification [IDA, IGI, IMP]
- cell proliferation [IGI]
- cell-cell signaling [IMP]
- cellular response to lithium ion [IDA]
- central nervous system development [IMP]
- cerebellar granule cell precursor proliferation [IGI]
- determination of left/right asymmetry in lateral mesoderm [IMP]
- determination of left/right symmetry [IMP]
- developmental growth [IMP]
- digestive tract mesoderm development [ISO]
- digestive tract morphogenesis [IMP]
- dorsal/ventral neural tube patterning [IDA, IGI, IMP]
- dorsal/ventral pattern formation [IGI]
- ectoderm development [IMP]
- embryo development [IGI, IMP]
- embryonic digestive tract morphogenesis [IMP, TAS]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic limb morphogenesis [IGI, IMP]
- embryonic morphogenesis [IMP]
- embryonic organ development [IMP]
- embryonic skeletal system development [IGI]
- endocytosis [IDA]
- epithelial cell proliferation involved in salivary gland morphogenesis [IMP]
- epithelial tube branching involved in lung morphogenesis [IMP]
- epithelial-mesenchymal cell signaling [IMP]
- epithelial-mesenchymal signaling involved in prostate gland development [IGI, ISO]
- establishment of cell polarity [IDA]
- forebrain development [IGI]
- formation of anatomical boundary [IMP]
- fungiform papilla development [ISO]
- fungiform papilla formation [ISO]
- fungiform papilla morphogenesis [ISO]
- hair follicle development [IMP]
- hair follicle morphogenesis [IMP]
- heart development [IMP]
- heart looping [IMP]
- hindbrain development [IGI, IMP]
- hindgut morphogenesis [IMP]
- inner ear development [IGI, IMP]
- intermediate filament organization [IMP]
- kidney development [IMP]
- left lung development [IMP]
- limb bud formation [IMP]
- limb development [IGI, IMP]
- lung development [IGI, IMP]
- lung epithelium development [IMP]
- lung lobe morphogenesis [IMP]
- lung morphogenesis [IMP]
- lung-associated mesenchyme development [IMP]
- lymphoid progenitor cell differentiation [IMP, ISO]
- male genitalia development [IMP]
- male genitalia morphogenesis [ISO]
- mesenchymal cell proliferation [IMP]
- mesenchymal cell proliferation involved in lung development [IDA]
- mesenchymal smoothened signaling pathway involved in prostate gland development [IMP]
- metanephric mesenchymal cell proliferation involved in metanephros development [IMP]
- metanephros development [IMP]
- midbrain development [IGI]
- multicellular structure septum development [IMP]
- myoblast differentiation [IDA]
- myotube differentiation [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of alpha-beta T cell differentiation [IMP]
- negative regulation of apoptotic process [IDA, IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell differentiation [IDA, IMP]
- negative regulation of cell migration [IDA]
- negative regulation of cholesterol efflux [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of kidney smooth muscle cell differentiation [IDA]
- negative regulation of mesenchymal cell apoptotic process [IMP]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription elongation from RNA polymerase II promoter [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of ureter smooth muscle cell differentiation [IDA]
- negative thymic T cell selection [IMP]
- neural crest cell migration [IMP]
- neural tube formation [ISO]
- neuroblast proliferation [IDA]
- neuron fate commitment [IMP]
- odontogenesis [IDA]
- odontogenesis of dentin-containing tooth [IMP]
- oligodendrocyte development [IDA]
- oligodendrocyte differentiation [IGI]
- organ formation [IMP]
- osteoblast development [IDA]
- palate development [IMP]
- pancreas development [IGI, IMP]
- pattern specification process [IGI, IMP]
- patterning of blood vessels [IMP]
- polarity specification of anterior/posterior axis [IMP]
- positive regulation of T cell differentiation in thymus [IMP]
- positive regulation of Wnt signaling pathway [IMP]
- positive regulation of alpha-beta T cell differentiation [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell division [ISO]
- positive regulation of cell proliferation [IDA, IGI, IMP, ISO]
- positive regulation of cerebellar granule cell precursor proliferation [IDA]
- positive regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of hh target transcription factor activity [IDA, IGI, IMP]
- positive regulation of immature T cell proliferation in thymus [IMP]
- positive regulation of kidney smooth muscle cell differentiation [IDA]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of mesenchymal cell proliferation involved in ureter development [IMP]
- positive regulation of neuroblast proliferation [IDA, ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of oligodendrocyte differentiation [IDA]
- positive regulation of oligodendrocyte progenitor proliferation [ISO]
- positive regulation of penile erection [ISO]
- positive regulation of photoreceptor cell differentiation [ISO]
- positive regulation of protein import into nucleus [IGI]
- positive regulation of sclerotome development [ISO]
- positive regulation of skeletal muscle cell proliferation [IMP]
- positive regulation of skeletal muscle tissue development [IMP]
- positive regulation of smoothened signaling pathway [IMP, ISO]
- positive regulation of striated muscle cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of ureter smooth muscle cell differentiation [IMP]
- positive thymic T cell selection [IMP]
- primary prostatic bud elongation [IDA]
- prostate epithelial cord elongation [IDA]
- prostate gland development [IMP]
- prostatic bud formation [IGI]
- protein localization to nucleus [IDA]
- regulation of cell proliferation [IDA, ISO]
- regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- regulation of gene expression [IDA, IGI, IMP, ISO]
- regulation of mesenchymal cell proliferation involved in prostate gland development [IMP]
- regulation of odontogenesis [IMP]
- regulation of prostatic bud formation [IDA, IMP]
- regulation of protein localization to nucleus [ISO]
- regulation of proteolysis [IDA]
- regulation of transcription, DNA-templated [IMP]
- respiratory tube development [IMP]
- response to axon injury [ISO]
- response to ethanol [ISO]
- right lung development [IMP]
- salivary gland cavitation [IDA]
- signal transduction [TAS]
- skin development [IMP]
- smoothened signaling pathway [IDA, IGI, IMP]
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [IDA, IMP]
- somite development [IMP]
- spinal cord dorsal/ventral patterning [IMP, ISO]
- spinal cord motor neuron differentiation [IGI]
- stem cell development [IMP]
- striated muscle cell differentiation [IDA, IMP]
- striated muscle tissue development [IMP]
- telencephalon regionalization [IMP, ISO]
- thalamus development [IGI, IMP]
- thymus development [IMP]
- thyroid gland development [IMP]
- tongue development [ISO]
- tongue morphogenesis [ISO]
- trachea development [IMP]
- trachea morphogenesis [IMP]
- vasculature development [IMP]
- vasculogenesis [IDA]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventral spinal cord interneuron specification [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.
Loss-of-function mutations in glypican-3 (GPC3), one of the six mammalian glypicans, causes the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and GPC3 null mice display developmental overgrowth. Because the Hedgehog signaling pathway positively regulates body size, we hypothesized that GPC3 acts as an inhibitor of Hedgehog activity during development. Here, we show that GPC3 null embryos display increased Hedgehog signaling and that GPC3 ... [more]
Dev. Cell May. 01, 2008; 14(5);700-11 [Pubmed: 18477453]
Throughput
- Low Throughput
Curated By
- BioGRID