FBXL7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AURKA
Gene Ontology Biological Process
- anterior/posterior axis specification [IMP]
- centrosome localization [IMP]
- centrosome organization [IGI]
- histone-serine phosphorylation [IMP]
- meiotic nuclear division [IMP]
- meiotic spindle organization [IMP]
- microtubule cytoskeleton organization [IGI]
- mitotic cell cycle [IMP]
- mitotic centrosome separation [IGI, IMP]
- mitotic nuclear division [IMP]
- mitotic spindle organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of spindle checkpoint [IMP]
- neuron projection extension [IGI]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- protein localization to centrosome [IMP]
- protein phosphorylation [IBA, IGI, ISO]
- regulation of cytokinesis [IBA]
- regulation of protein stability [ISO]
- spindle assembly involved in female meiosis I [IMP]
- spindle stabilization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon hillock [IDA]
- centrosome [IDA, ISO]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- germinal vesicle [IDA]
- meiotic spindle [IDA]
- microtubule cytoskeleton [ISO]
- microtubule organizing center [IGI]
- mitotic spindle [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- pronucleus [IDA]
- spindle [ISO]
- spindle microtubule [IBA, ISO]
- spindle midzone [IBA]
- spindle pole centrosome [IBA, ISO]
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.
Aurora family kinases play pivotal roles in several steps during mitosis. Specifically, Aurora A kinase is an important regulator of bipolar mitotic spindle formation and chromosome segregation. Like other members of the Aurora family, Aurora A kinase is also regulated by post-translational modifications. Here, we show that a previously undescribed E3 ligase component belonging to the SCF (Skp-Cullin1-F-box protein) E3 ... [more]
Throughput
- Low Throughput
Additional Notes
- E1,
- Purified SCFFBXL7 ( Cullin1, Skp1, Rbx1 and FBXL7)
- e2- Ubc5, Ubc7
Curated By
- BioGRID