IFI204
Gene Ontology Biological Process
- cellular response to interferon-beta [IDA]
- inner ear development [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of osteoblast differentiation [IGI]
- regulation of nucleic acid-templated transcription [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- core promoter binding [ISO]
- double-stranded DNA binding [IDA, ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- transcription cofactor activity [IGI]
- transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- core promoter binding [ISO]
- double-stranded DNA binding [IDA, ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- transcription cofactor activity [IGI]
- transcription factor binding [ISO]
RUNX2
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- T cell differentiation [IDA]
- cell maturation [IGI, IMP]
- cellular response to BMP stimulus [IMP]
- chondrocyte development [IMP]
- chondrocyte differentiation [IGI, IMP]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic forelimb morphogenesis [IMP]
- endochondral ossification [IMP]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- odontogenesis of dentin-containing tooth [IMP]
- osteoblast development [IGI]
- osteoblast differentiation [IGI, IMP]
- osteoblast fate commitment [IGI]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of ossification [ISO]
- positive regulation of osteoblast differentiation [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- regulation of odontogenesis of dentin-containing tooth [IMP]
- regulation of ossification [IMP]
- regulation of osteoblast differentiation [IDA]
- regulation of transcription, DNA-templated [TAS]
- skeletal system development [IMP]
- skeletal system morphogenesis [IMP]
- stem cell differentiation [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- bHLH transcription factor binding [IPI]
- chromatin binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.
The differentiation of uncommitted mesenchymal cells into osteoblasts is a fundamental molecular event governing both embryonic development and bone repair. The bone morphogenetic proteins (BMPs) are important regulators of this process; they function by binding to cell surface receptors and signaling by means of Smad proteins. Core binding factor alpha-1 (Cbfa1), a member of the runt family of transcription factors, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IFI204 RUNX2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID