IL6ST
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [ISO]
- cytokine-mediated signaling pathway [IDA, ISO]
- glycogen metabolic process [IMP]
- interleukin-27-mediated signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- leukemia inhibitory factor signaling pathway [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of interleukin-6-mediated signaling pathway [ISO]
- oncostatin-M-mediated signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- regulation of Notch signaling pathway [IDA]
- response to cytokine [ISO]
- signal transduction [IDA]
- triglyceride mobilization [ISO]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- cell body [IDA]
- ciliary neurotrophic factor receptor complex [ISO]
- cytosol [ISO]
- dendrite [IDA]
- external side of plasma membrane [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- interleukin-6 receptor complex [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- neuronal cell body membrane [ISO]
- oncostatin-M receptor complex [ISO]
LIFR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Evidence for heterodimeric association of leukemia inhibitory factor (LIF) receptor and gp130 in the mouse uterus for LIF signaling during blastocyst implantation.
Implantation failure in mice lacking leukemia inhibitory factor (LIF) establishes that this cytokine is crucial to this process. LIF transcripts are expressed in the uterus in a biphasic manner: LIF is expressed in the gland on the morning of day 4 and again in stromal cells surrounding the blastocyst with the onset of implantation in the evening of day 4 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID