BAIT
ADIPOQ
30kDa, APN, Acdc, Acrp30, GBP28, adipo, apM1
adiponectin, C1Q and collagen domain containing
GO Process (66)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- adiponectin-activated signaling pathway [ISO]
- brown fat cell differentiation [IDA]
- cellular response to cAMP [ISO]
- cellular response to drug [IDA]
- cellular response to epinephrine stimulus [ISO]
- cellular response to insulin stimulus [IGI, ISO]
- detection of oxidative stress [IMP]
- fatty acid beta-oxidation [IMP]
- fatty acid oxidation [IDA]
- glucose homeostasis [IDA, IMP]
- glucose metabolic process [IDA, IMP]
- low-density lipoprotein particle clearance [ISO]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of blood pressure [ISO]
- negative regulation of cell migration [IDA]
- negative regulation of fat cell differentiation [IDA, ISO]
- negative regulation of gluconeogenesis [IDA]
- negative regulation of granulocyte differentiation [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of hormone secretion [ISO]
- negative regulation of inflammatory response [IDA]
- negative regulation of intracellular protein transport [ISO]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of macrophage differentiation [ISO]
- negative regulation of metanephric mesenchymal cell migration [IDA]
- negative regulation of phagocytosis [ISO]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA, ISO]
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [IDA]
- negative regulation of protein autophosphorylation [ISO]
- negative regulation of receptor binding [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of synaptic transmission [ISO]
- negative regulation of transcription, DNA-templated [IMP, ISO]
- negative regulation of tumor necrosis factor production [ISO]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of blood pressure [ISO]
- positive regulation of cAMP-dependent protein kinase activity [IMP, ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of fatty acid metabolic process [IMP]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen (starch) synthase activity [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of metanephric glomerular visceral epithelial cell development [IMP]
- positive regulation of monocyte chemotactic protein-1 production [ISO]
- positive regulation of myeloid cell apoptotic process [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein kinase A signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of renal albumin absorption [IMP, ISO]
- positive regulation of signal transduction [IDA]
- protein heterotrimerization [IPI]
- protein homooligomerization [IDA, ISO]
- protein localization to plasma membrane [ISO]
- regulation of glucose metabolic process [ISO]
- response to glucose [IDA, IMP]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDH13
4932416G01Rik, Cdht, T-cadherin, Tcad
cadherin 13
GO Process (22)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- Rho protein signal transduction [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISO]
- endothelial cell migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- keratinocyte proliferation [ISO]
- lamellipodium assembly [ISO]
- localization within membrane [ISO]
- low-density lipoprotein particle mediated signaling [ISO]
- negative regulation of cell adhesion [ISO]
- negative regulation of cell proliferation [ISO]
- positive regulation of calcium-mediated signaling [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of cell growth [ISO]
- regulation of endocytosis [ISO]
- regulation of epidermal growth factor receptor signaling pathway [ISO]
- sprouting angiogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin.
Acrp30/adiponectin is reduced in the serum of obese and diabetic individuals, and the genetic locus of adiponectin is linked to the metabolic syndrome. Recombinant adiponectin, administered to diet-induced obese mice, induced weight loss and improved insulin sensitivity. In muscle and liver, adiponectin stimulates AMP-activated protein kinase activation and fatty acid oxidation. To expression-clone molecules capable of binding adiponectin, we transduced ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jul. 13, 2004; 101(28);10308-13 [Pubmed: 15210937]
Throughput
- Low Throughput
Curated By
- BioGRID