STAT5A
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [IMP]
- JAK-STAT cascade [IDA, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA]
- Peyer's patch development [IGI]
- T cell differentiation in thymus [IGI]
- T cell homeostasis [IGI]
- allantoin metabolic process [IMP]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- citrate metabolic process [IMP]
- creatine metabolic process [IMP]
- creatinine metabolic process [IMP]
- cytokine-mediated signaling pathway [IDA]
- development of secondary female sexual characteristics [IMP]
- development of secondary male sexual characteristics [IGI, IMP]
- epithelial cell differentiation involved in prostate gland development [IMP]
- fatty acid metabolic process [IMP]
- female pregnancy [IGI]
- isoleucine metabolic process [IMP]
- lactation [IMP]
- lipid storage [IGI]
- luteinization [IGI]
- mammary gland development [IMP]
- mammary gland epithelium development [IGI, IMP]
- mammary gland involution [ISO]
- natural killer cell differentiation [IGI]
- negative regulation of apoptotic process [IGI]
- negative regulation of erythrocyte differentiation [IGI]
- negative regulation of mast cell apoptotic process [IMP]
- oxaloacetate metabolic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of B cell differentiation [IGI]
- positive regulation of activated T cell proliferation [IDA, IGI]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of gamma-delta T cell differentiation [IGI]
- positive regulation of inflammatory response [IGI]
- positive regulation of interleukin-2 biosynthetic process [IGI]
- positive regulation of lymphocyte differentiation [IGI]
- positive regulation of mast cell differentiation [IMP]
- positive regulation of mast cell proliferation [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of multicellular organism growth [IGI]
- positive regulation of natural killer cell differentiation [IMP]
- positive regulation of natural killer cell mediated cytotoxicity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- prolactin signaling pathway [IDA]
- prostate gland epithelium morphogenesis [IMP]
- regulation of cell adhesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of multicellular organism growth [IDA]
- regulation of steroid metabolic process [IGI]
- regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of transcription, DNA-templated [ISO]
- response to peptide hormone [IDA]
- signal transduction [IGI]
- succinate metabolic process [IMP]
- taurine metabolic process [IMP]
- transcription from RNA polymerase II promoter [ISO]
- valine metabolic process [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- signal transducer activity [IGI]
- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- signal transducer activity [IGI]
AGAP2
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.
PI 3-kinase enhancer A (PIKE-A) is critical for the activation of Akt signalling, and has an essential function in promoting cancer cell survival. However, its physiological functions are poorly understood. Here, we show that PIKE-A directly associates with both signal transducer and activator of transcription 5a (STAT5a) and prolactin (PRL) receptor, which is essential for PRL-provoked STAT5a activation and the ... [more]
Throughput
- Low Throughput
Additional Notes
- PIKE-A
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGAP2 STAT5A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 860344 |
Curated By
- BioGRID