PRLR
Gene Ontology Biological Process
- JAK-STAT cascade [IMP]
- activation of transmembrane receptor protein tyrosine kinase activity [ISO]
- lactation [IGI, IMP]
- mammary gland alveolus development [IGI, IMP]
- mammary gland epithelial cell differentiation [IGI]
- mammary gland epithelium development [IMP]
- prolactin signaling pathway [IMP, ISO]
- prostate gland growth [IMP]
- regulation of cell adhesion [IMP]
- regulation of epithelial cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AGAP2
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.
PI 3-kinase enhancer A (PIKE-A) is critical for the activation of Akt signalling, and has an essential function in promoting cancer cell survival. However, its physiological functions are poorly understood. Here, we show that PIKE-A directly associates with both signal transducer and activator of transcription 5a (STAT5a) and prolactin (PRL) receptor, which is essential for PRL-provoked STAT5a activation and the ... [more]
Throughput
- Low Throughput
Additional Notes
- PIKE-A
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AGAP2 PRLR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 860343 |
Curated By
- BioGRID