SALL4
Gene Ontology Biological Process
- embryonic limb morphogenesis [IGI, IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- inner cell mass cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neural tube closure [IGI, IMP]
- neural tube development [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- stem cell maintenance [IMP]
- tissue development [IMP]
- ventricular septum development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TBX5
Gene Ontology Biological Process
- apoptotic nuclear changes [ISO]
- atrial septum development [IMP]
- atrial septum morphogenesis [IGI]
- atrioventricular valve morphogenesis [IGI]
- bundle of His development [IGI]
- cardiac left ventricle formation [IMP]
- cardiac muscle cell differentiation [IGI, IMP]
- cell-cell signaling [ISO]
- embryonic forelimb morphogenesis [IMP, ISO]
- embryonic limb morphogenesis [IGI, IMP, ISO]
- endocardial cushion development [IGI]
- forelimb morphogenesis [IMP, ISO]
- heart development [IMP, ISO]
- lung development [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- pattern specification process [IMP]
- pericardium development [ISO]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cardioblast differentiation [ISO]
- positive regulation of secondary heart field cardioblast proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [IMP]
- transcription from RNA polymerase II promoter [IDA]
- transdifferentiation [ISO]
- ventricular cardiac muscle tissue development [IGI]
- ventricular septum development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Human mutations in TBX5, a gene encoding a T-box transcription factor, and SALL4, a gene encoding a zinc-finger transcription factor, cause similar upper limb and heart defects. Here we show that Tbx5 regulates Sall4 expression in the developing mouse forelimb and heart; mice heterozygous for a gene trap allele of Sall4 show limb and heart defects that model human disease. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID