HSPA8
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- chaperone mediated protein folding requiring cofactor [IGI, ISO]
- chaperone-mediated protein folding [ISO]
- clathrin coat disassembly [IGI]
- negative regulation of fibril organization [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- protein folding [IDA]
- protein refolding [ISO]
- regulation of cell cycle [IDA]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled [IDA, ISO]
- G-protein coupled receptor binding [ISO]
- MHC class II protein complex binding [ISO]
- enzyme binding [ISO]
- heat shock protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IPI, ISO]
Gene Ontology Cellular Component
- Prp19 complex [ISO]
- blood microparticle [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [IDA, ISO]
- focal adhesion [ISO]
- intracellular [IDA]
- membrane [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [ISO]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
- ubiquitin ligase complex [ISO]
CDK4
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- negative regulation of cell cycle arrest [ISO]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell size [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cell cycle [IDA]
- regulation of cell proliferation [IMP]
- regulation of gene expression [ISO]
- response to drug [ISO]
- response to lead ion [ISO]
- response to organic substance [ISO]
- response to testosterone [ISO]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase.
The cyclin D-dependent kinase is a critical mediator of mitogen-dependent G1 phase progression in mammalian cells. Given the high incidence of cyclin D1 overexpression in human neoplasias, the nature and complexity of cyclin D complexes in vivo have been subjects of intense interest. Besides its catalytic partner, the nature and complexity of cyclin D complexes in vivo remain ambiguous. To ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID