NDEL1
Gene Ontology Biological Process
- activation of Cdc42 GTPase activity [IDA]
- canonical Wnt signaling pathway [IMP]
- cell migration [IMP]
- central nervous system neuron axonogenesis [IMP]
- centrosome localization [IMP]
- cerebral cortex radially oriented cell migration [IMP]
- chromosome segregation [IBA, ISO]
- establishment of chromosome localization [IBA]
- establishment of mitotic spindle orientation [IBA]
- inner cell mass cell proliferation [IMP]
- microtubule cytoskeleton organization [IGI]
- microtubule nucleation [IBA]
- mitotic centrosome separation [IGI, IMP]
- neurofilament cytoskeleton organization [IMP]
- neuron migration [IGI]
- neuron projection development [ISO]
- neuron projection extension [IGI]
- nuclear envelope disassembly [ISS]
- positive regulation of axon extension [ISO]
- positive regulation of axon regeneration [ISO]
- proteolysis [ISO]
- regulation of neuron projection development [IMP, ISO]
- retrograde axon cargo transport [IDA]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARHGAP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Cdc42GAP promotes inactivation of Cdc42, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration. How Cdc42GAP is regulated to ensure proper levels of active Cdc42 is poorly understood. Here we show that Nudel, a cytoplasmic dynein regulator, competes with Cdc42 for binding Cdc42GAP. Consequently, Nudel can inhibit Cdc42GAP-mediated inactivation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDEL1 ARHGAP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ARHGAP1 NDEL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID