SOST
Gene Ontology Biological Process
- cellular response to parathyroid hormone stimulus [ISO]
- negative regulation of BMP signaling pathway [IDA, ISA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- negative regulation of canonical Wnt signaling pathway [IGI, ISO]
- negative regulation of ossification [IMP]
- negative regulation of protein complex assembly [ISO]
- ossification [IDA]
- positive regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LRP5
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IGI, ISO]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IBA, ISO]
- adipose tissue development [IBA, ISO]
- anatomical structure regression [IMP]
- anterior/posterior pattern specification [IGI]
- apoptotic process involved in patterning of blood vessels [IMP]
- bone development [IMP]
- bone marrow development [IBA, ISO]
- bone morphogenesis [IBA, ISO]
- bone remodeling [IGI, IMP]
- branching involved in mammary gland duct morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IMP, ISO]
- cell migration involved in gastrulation [IGI]
- cell-cell signaling involved in mammary gland development [IMP]
- cholesterol homeostasis [IBA, ISO]
- cholesterol metabolic process [IMP]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic digit morphogenesis [IGI]
- embryonic retina morphogenesis in camera-type eye [IBA]
- extracellular matrix-cell signaling [IDA]
- gastrulation with mouth forming second [IGI]
- glucose catabolic process [ISO]
- limb morphogenesis [IGI]
- mammary gland duct morphogenesis [IGI]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- osteoblast development [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of apoptotic process [IMP]
- regulation of blood pressure [ISO]
- regulation of bone remodeling [IMP]
- regulation of canonical Wnt signaling pathway [ISO]
- regulation of fat cell differentiation [IBA]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of ossification [IBA]
- retina morphogenesis in camera-type eye [ISO]
- retina vasculature morphogenesis in camera-type eye [IGI, IMP]
- retinal blood vessel morphogenesis [IBA, ISO]
- somatic stem cell maintenance [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.
We compared and contrasted the mechanism of action for the cysteine knot protein subfamily, Wise and Sost (Sclerostin). Our data suggest that functional interactions between Sost or Wise and LRP5/LRP6 have the potential to regulate bone deposition by modulating the Wnt pathway.The human disease sclerosteosis exhibits an increase in bone mass thought to be caused by hyperactive osteoblasts. Sclerostin, SOST, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID