CAMK2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRM4
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS]
- gamma-aminobutyric acid secretion [TAS]
- learning [ISO]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of synaptic transmission [TAS]
- neuron projection development [TAS]
- positive regulation of MAPK cascade [ISO]
- regulation of neuron apoptotic process [NAS]
- regulation of synaptic transmission, glutamatergic [IBA]
- synaptic transmission [ISO]
- synaptic transmission, GABAergic [TAS]
- synaptic transmission, glutamatergic [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Determining calmodulin binding to metabotropic glutamate receptors with distinct protein-interaction methods.
mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that modulate synaptic transmission. The eight mammalian mGluRs form three groups based on sequence and functional similarities: group I (1 and 5), group II (2 and 3) and group III (4, 6-8) mGluRs. In the present study, we used a Y2H (yeast two hybrid) screen to identify proteins that interact with the C-terminal ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 2.
Curated By
- BioGRID