CAMK2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRM7
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA, ISO]
- adult behavior [ISO]
- associative learning [ISO]
- behavioral fear response [ISO]
- calcium ion transmembrane transport [ISO]
- conditioned taste aversion [ISO]
- learning or memory [TAS]
- memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [IDA]
- neurological system process [ISO]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [ISO]
- synaptic transmission [ISO]
- transmission of nerve impulse [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- asymmetric synapse [IDA]
- axon [IDA]
- axon terminus [IDA]
- cell cortex [ISO]
- cell surface [IDA]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [IDA]
- neuronal cell body [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA, ISO]
- protein complex [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- synapse [IDA]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Determining calmodulin binding to metabotropic glutamate receptors with distinct protein-interaction methods.
mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that modulate synaptic transmission. The eight mammalian mGluRs form three groups based on sequence and functional similarities: group I (1 and 5), group II (2 and 3) and group III (4, 6-8) mGluRs. In the present study, we used a Y2H (yeast two hybrid) screen to identify proteins that interact with the C-terminal ... [more]
Throughput
- Low Throughput
Additional Notes
- data not shown
Curated By
- BioGRID