RPS6KA3
Gene Ontology Biological Process
Gene Ontology Molecular Function
FBXO5
Gene Ontology Biological Process
- inhibition of mitotic anaphase-promoting complex activity [ISO]
- microtubule polymerization [IDA]
- negative regulation of meiosis [IDA]
- negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle [ISO]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [ISO]
- oocyte maturation [IDA, IMP]
- positive regulation of meiosis I [ISO]
- regulation of meiosis [IDA]
- regulation of mitotic cell cycle [IMP]
- spindle assembly [IDA]
- spindle assembly involved in female meiosis I [IDA]
- vesicle organization [IDA]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Functional interaction between p90Rsk2 and Emi1 contributes to the metaphase arrest of mouse oocytes.
Vertebrate eggs arrest at metaphase of the second meiotic division before fertilization under the effect of a cytostatic factor (CSF). This arrest is established during oocyte maturation by the MAPK kinase module, comprised of Mos, MEK, MAPKs and p90Rsk. Maintenance of CSF arrest at metaphase requires inhibitors of the anaphase-promoting complex (APC) like Emi1, which sequesters the APC activator Cdc20. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID