BAIT
SCN5A
Nav1.5, Nav1.5c, SkM1, SkM2, mH1
sodium channel, voltage-gated, type V, alpha
GO Process (31)
GO Function (13)
GO Component (10)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISO]
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [ISO]
- bundle of His cell to Purkinje myocyte communication [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cardiac muscle contraction [ISO]
- cardiac ventricle development [IMP]
- cellular response to calcium ion [ISO]
- membrane depolarization [ISO]
- membrane depolarization during SA node cell action potential [IMP]
- membrane depolarization during action potential [ISO]
- membrane depolarization during cardiac muscle cell action potential [ISO]
- neuronal action potential [IBA]
- positive regulation of action potential [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of heart rate [ISO]
- positive regulation of sodium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of cardiac muscle cell contraction [IMP, ISO]
- regulation of heart rate [ISO]
- regulation of heart rate by cardiac conduction [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of sodium ion transmembrane transport [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to denervation involved in regulation of muscle adaptation [ISO]
- response to organic cyclic compound [IMP]
- sodium ion transmembrane transport [IMP, ISO]
- sodium ion transport [IDA, ISO]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- ankyrin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IDA, ISO]
- voltage-gated sodium channel activity involved in SA node cell action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP, ISO]
- ankyrin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- fibroblast growth factor binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- scaffold protein binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- voltage-gated sodium channel activity [IDA, ISO]
- voltage-gated sodium channel activity involved in SA node cell action potential [IMP]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [IMP, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
NEDD4
AA959633, AL023035, AU019897, E430025J12Rik, Nedd4-1, Nedd4a, mKIAA0093
neural precursor cell expressed, developmentally down-regulated 4
GO Process (16)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.
Nedd4 and Nedd4-2 are ubiquitin-protein ligases known to regulate a number of membrane proteins including receptors and ion transporters. Regulation of the epithelial Na(+) channel by Nedd4 and Nedd4-2 is mediated via interactions between the PY motifs of the epithelial sodium channel subunits and the Nedd4/Nedd4-2 WW domains. This example serves as a model for the regulation of other PY ... [more]
J. Biol. Chem. Jul. 09, 2004; 279(28);28930-5 [Pubmed: 15123669]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEDD4 SCN5A | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - |
Curated By
- BioGRID