BAIT
GRM8
A230002O04, Gprc1h, mGluR8
glutamate receptor, metabotropic 8
GO Process (7)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA, ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- regulation of neurotransmitter secretion [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- synaptic transmission [ISO, TAS]
- synaptic transmission, glutamatergic [ISO, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SUMO1
small ubiquitin-like modifier 1
GO Process (14)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- PML body organization [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [ISO, ISS]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [ISO]
- protein sumoylation [ISO, ISS]
- regulation of calcium ion transmembrane transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of protein stability [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.
Group III presynaptic metabotropic glutamate receptors (mGluRs) play a central role in regulating presynaptic activity through G-protein effects on ion channels and signal transducing enzymes. Like all Class C G-protein-coupled receptors, mGluR8 has an extended intracellular C-terminal domain (CTD) presumed to allow for modulation of downstream signaling. In a yeast two-hybrid screen of an adult rat brain cDNA library with ... [more]
J. Biol. Chem. Nov. 18, 2005; 280(46);38153-9 [Pubmed: 16144832]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID