FXYD3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATP1A1
Gene Ontology Biological Process
- ATP catabolic process [ISO, TAS]
- cardiac muscle contraction [TAS]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [IDA]
- cellular response to steroid hormone stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- dephosphorylation [ISO]
- energy coupled proton transmembrane transport, against electrochemical gradient [TAS]
- membrane hyperpolarization [IMP]
- membrane repolarization [ISO]
- negative regulation of glucocorticoid biosynthetic process [ISO]
- negative regulation of heart contraction [ISO]
- positive regulation of heart contraction [ISO]
- positive regulation of striated muscle contraction [ISO]
- potassium ion import [IDA, ISO]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [IDA]
- regulation of blood pressure [ISO]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of sodium ion transport [IDA]
- regulation of the force of heart contraction [ISO]
- relaxation of cardiac muscle [TAS]
- response to drug [ISO]
- response to glycoside [ISO]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IDA, ISO]
- sodium ion transport [IDA]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ankyrin binding [IPI]
- chaperone binding [IDA, ISO]
- phosphatase activity [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- sodium ion binding [IDA]
- sodium:potassium-exchanging ATPase activity [IDA, ISO]
- steroid hormone binding [ISO]
- ADP binding [IDA]
- ATP binding [IDA]
- ankyrin binding [IPI]
- chaperone binding [IDA, ISO]
- phosphatase activity [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- sodium ion binding [IDA]
- sodium:potassium-exchanging ATPase activity [IDA, ISO]
- steroid hormone binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- T-tubule [IDA, ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- caveola [IDA]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISS]
- intercalated disc [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- myelin sheath [ISO]
- neuronal postsynaptic density [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sodium:potassium-exchanging ATPase complex [IDA, ISO]
- vesicle [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
FXYD3 (Mat-8), a new regulator of Na,K-ATPase.
Four of the seven members of the FXYD protein family have been identified as specific regulators of Na,K-ATPase. In this study, we show that FXYD3, also known as Mat-8, is able to associate with and to modify the transport properties of Na,K-ATPase. In addition to this shared function, FXYD3 displays some uncommon characteristics. First, in contrast to other FXYD proteins, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID